Dizerega G S, Hodgen G D
Fertil Steril. 1981 Apr;35(4):428-32.
Previously, we demonstrated that selective suppression of serum follicle-stimulating hormone (FSH) in monkeys treated with charcoal-extracted porcine follicular fluid (pFF) in the early follicular phase induced luteal defects resembling those which occur spontaneously in women and monkeys. Here, we assessed whether luteal phase defects arising in association with induced FSH deficiencies during the early follicular phase can be treated by early FSH therapy. Rhesus monkeys were treated with pFF and human menopausal gonadotropin (hMG) (FSH:luteinizing hormone [LH], 3:1) on cycle days 1 to 3 or day 4, respectively. Daily femoral blood samples were analyzed for LH, FSH, and estradiol by radioimmunoassay. In the monkeys treated with the pFF-hMG combination, a single ovulation was uniformly noted at laparoscopy, and initial luteal phase elevations in serum progesterone levels were nearer those of normal ovulatory cycles than after pFF alone. These results suggest that FSH/LH treatment in the early follicular phase compensated, in part, for the pFF-induced deficiency in endogenous FSH levels.
此前，我们证明，在卵泡期早期用经活性炭提取的猪卵泡液（pFF）处理的猴子中，选择性抑制血清促卵泡激素（FSH）会导致黄体缺陷，类似于在女性和猴子中自然发生的情况。在此，我们评估了在卵泡期早期与诱导性FSH缺乏相关的黄体期缺陷是否可以通过早期FSH治疗来治疗。恒河猴分别在周期第1至3天或第4天接受pFF和人绝经期促性腺激素（hMG）（FSH：促黄体生成素[LH]，3：1）治疗。通过放射免疫分析法对每日采集的股静脉血样本进行LH、FSH和雌二醇分析。在用pFF-hMG组合治疗的猴子中，腹腔镜检查均发现单一排卵，且血清孕酮水平的初始黄体期升高比单独使用pFF后更接近正常排卵周期。这些结果表明，卵泡期早期的FSH/LH治疗部分补偿了pFF诱导的内源性FSH水平缺乏。
