Stein D C, Hebeler B H, Young F E
Infect Immun. 1980 Aug;29(2):507-11. doi: 10.1128/iai.29.2.507-511.1980.
The effect of environmental variation on the susceptibility of Neisseria gonorrhoeae to pyocin produced by Pseudomonas aeruginosa was examined. Susceptibility to at least one pyocin was demonstrated in strains of N. gonorrhoeae (99%), N. meningitidis (35%), and N. lactamica (47%). The degree of sensitivity to pyocin displayed by N. gonorrhoeae was affected by varying the pH of the growth environment. Gonococcal strains were more sensitive to growth inhibition by pyocins at an alkaline pH and less sensitive to growth inhibition at an acid pH. Inhibitory titers fluctuated during nonselective subculture of fresh clinical isolates. There was no apparent correlation between auxotype and sensitivity to pyocin. Also, no relationship between colony morphology and pyocin sensitivity was seen.
研究了环境变化对淋病奈瑟菌对铜绿假单胞菌产生的绿脓菌素敏感性的影响。在淋病奈瑟菌菌株(99%)、脑膜炎奈瑟菌菌株(35%)和乳糖奈瑟菌菌株(47%)中均显示出对至少一种绿脓菌素的敏感性。通过改变生长环境的pH值,淋病奈瑟菌对绿脓菌素的敏感程度受到影响。淋球菌菌株在碱性pH值下对绿脓菌素的生长抑制更敏感,而在酸性pH值下对生长抑制较不敏感。在新鲜临床分离株的非选择性传代培养过程中,抑制效价会发生波动。营养型与对绿脓菌素的敏感性之间没有明显的相关性。此外,未观察到菌落形态与绿脓菌素敏感性之间的关系。