绿脓菌素对淋病奈瑟菌的抑制作用：作用机制
Pyocin inhibition of Neisseria gonorrhoeae: mechanism of action.
作者信息
Morse S A, Jones B V, Lysko P G
出版信息
Antimicrob Agents Chemother. 1980 Sep;18(3):416-23. doi: 10.1128/AAC.18.3.416.
Abstract
Purified R-type pyocins (611 131) from Pseudomonas aeruginosa PA103 exhibited bactericidal activity against Neisseria gonorrhoeae. Killing of gonococci was a single-hit process requiring as few as 1 pyocin per colony-forming unit. Deoxyriboinucleic acid, ribonucleic acid, protein, and lipid syntheses were rapidly and completely inhibited. Oxygen uptake was also inhibited, but occurred after the inhibition of macromolecular synthesis. The cell lysis which occurred after pyocin inhibition of gonococcal growth was the result of endogenous gonococcal autolysin activity.
摘要
从铜绿假单胞菌PA103中纯化得到的R型绿脓菌素（611 131）对淋病奈瑟菌具有杀菌活性。杀灭淋球菌是一个单打击过程，每个集落形成单位只需1个绿脓菌素。脱氧核糖核酸、核糖核酸、蛋白质和脂质合成迅速且完全受到抑制。氧气摄取也受到抑制，但发生在大分子合成受到抑制之后。绿脓菌素抑制淋球菌生长后发生的细胞裂解是淋球菌内源性自溶素活性的结果。
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