Käyhty H, Jousimies-Somer H, Peltola H, Mäketä P H
J Infect Dis. 1981 Jan;143(1):32-41. doi: 10.1093/infdis/143.1.32.
Levels of antibodies to the capsular polysaccharides of groups A and C Neisseria meningitidis and Haemophilus influenzae type b were determined by radioimmunoassay in acute- and convalescent-phase sera of 377 patients with meningitis, septicemia, or epiglottitis. Diagnostic criteria, based on a fourfold or greater rise in antibody level and/or a high specific antibody level, correctly identified 85% of group A meningococcal diseases, 90% of group C meningococcal diseases, and 78% of H. influenzae type b diseases in children older than but only 15% in infants younger than 1.5 years of age. When levels of antibody in acute-phase sera were high, they were predominantly of the IgA class. A greater than fourfold rise in levels of antibodies to group A meningococcus was seen in 10%-32% of persons with disease caused by other bacteria, but minimal false-positive reactions occurred with group C meningococcus or H. influenzae type b.
采用放射免疫分析法，测定了377例患脑膜炎、败血症或会厌炎患者急性期和恢复期血清中抗A群和C群脑膜炎奈瑟菌及b型流感嗜血杆菌荚膜多糖的抗体水平。基于抗体水平升高四倍或更多和/或高特异性抗体水平的诊断标准，在1.5岁以上儿童中正确识别出85%的A群脑膜炎球菌病、90%的C群脑膜炎球菌病和78%的b型流感嗜血杆菌病，但在1.5岁以下婴儿中仅识别出15%。当急性期血清中的抗体水平较高时，主要为IgA类。在由其他细菌引起疾病的患者中，10%-32%的人抗A群脑膜炎球菌抗体水平升高四倍以上，但C群脑膜炎球菌或b型流感嗜血杆菌的假阳性反应极少。
