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免疫球蛋白同种异型与对流感嗜血杆菌和脑膜炎球菌多糖的免疫反应之间的关联。

Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides.

作者信息

Pandey J P, Fudenberg H H, Virella G, Kyong C U, Loadholt C B, Galbraith R M, Gotschlich E C, Parke J C

出版信息

Lancet. 1979 Jan 27;1(8109):190-2. doi: 10.1016/s0140-6736(79)90584-1.

Abstract

Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera were allotyped for several Gm, A2m, and Km antigens. A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children.

摘要

采集了20名健康白人婴儿和33名黑人婴儿在接种三剂白喉-百日咳-破伤风疫苗、一剂b型流感嗜血杆菌多聚核糖磷酸疫苗以及A群和C群脑膜炎球菌多糖疫苗前后的血清样本。检测了针对这些免疫原的抗体,并对血清进行了几种Gm、A2m和Km抗原的别型鉴定。在白人儿童中,发现Km(1)别型与对流感嗜血杆菌和C群脑膜炎球菌多糖的免疫反应(免疫接种后与免疫接种前抗体水平的差异)之间存在高度显著的关联。

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