Platonov A E, Beloborodov V B, Pavlova L I, Vershinina I V, Käyhty H
Central Institute of Epidemiology, Moscow, Russia.
Clin Exp Immunol. 1995 Apr;100(1):32-9. doi: 10.1111/j.1365-2249.1995.tb03600.x.
Eighteen patients with late complement component deficiency (LCCD) were immunized with meningococcal capsular polysaccharide vaccine. The LCCD patients had experienced one-to-five meningococcal infections before vaccination, but their immunological and clinical status was normal at the time of immunization. Serum samples from vaccinated complement-sufficient relatives of the LCCD patients and healthy Russian male adults were used as controls. Total and immunoglobulin-specific concentrations of antibodies to group A, C, W135, and Y capsular polysaccharides were determined by enzyme immunoassay in serum samples taken before and 1-108 weeks after immunization. The individual preimmunization and post-immunization antibody concentrations varied greatly. The median antibody concentrations of the LCCD patients increased significantly after vaccination, and were not significantly different from those of the control groups. The antibody concentrations remained elevated for at least 1 year after vaccination. The post-immunization antibody concentrations correlated with the number of meningococcal infections within 10 years before vaccination. In spite of the vaccination two LCCD patients experienced a meningococcal disease 9 and 12 months, respectively, after vaccination.
18名晚期补体成分缺陷（LCCD）患者接种了脑膜炎球菌荚膜多糖疫苗。LCCD患者在接种疫苗前曾经历过1至5次脑膜炎球菌感染，但在接种时其免疫和临床状况正常。将LCCD患者接种疫苗的补体充足的亲属以及健康的俄罗斯成年男性的血清样本用作对照。通过酶免疫测定法测定免疫前以及免疫后1至108周采集的血清样本中针对A、C、W135和Y荚膜多糖的抗体的总浓度和免疫球蛋白特异性浓度。个体免疫前和免疫后的抗体浓度差异很大。LCCD患者的抗体浓度中位数在接种疫苗后显著增加，且与对照组无显著差异。接种疫苗后抗体浓度至少在1年内保持升高。免疫后抗体浓度与接种疫苗前10年内的脑膜炎球菌感染次数相关。尽管接种了疫苗，仍有2名LCCD患者在接种疫苗后分别于9个月和12个月时发生了脑膜炎球菌病。
