布美他尼与速尿：健康男性剂量反应曲线的比较
Bumetanide and frusemide: a comparison of dose-response curves in healthy men.
作者信息
Ramsay L E, McInnes G T, Hettiarachchi J, Shelton J, Scott P
出版信息
Br J Clin Pharmacol. 1978 Mar;5(3):243-7. doi: 10.1111/j.1365-2125.1978.tb01631.x.
Abstract
1 Log dose-responses for the loop diuretics bumetanide and frusemide in healthy subjects deviated significantly from parallelism as regards urine volume and sodium excretion. Ignoring the nonparallelism the best estimate of natriuretic potency (bumetanide: frusemide) was 46:1 in the bumetanide dose range 0.5-2 mg. 2 For a given natriuresis the urinary potassium excretion following bumetanide was significantly lower than that for frusemide within this dose range. 3 The data illustrate the limitations of studies comparing diuretics at a single dose level. Extrapolation of the observed log dose-response curves provides one possible explanation for the relative potency (bumetanide: frusemide) of 20:1 reported when the drugs are used at high dosage in patients with renal failure.
摘要
- 健康受试者中，袢利尿剂布美他尼和呋塞米的对数剂量反应在尿量和钠排泄方面显著偏离平行性。忽略这种不平行性，在布美他尼剂量范围0.5 - 2毫克内，利钠效能（布美他尼：呋塞米）的最佳估计值为46:1。2. 在该剂量范围内，对于给定的利钠作用，布美他尼后的尿钾排泄显著低于呋塞米。3. 这些数据说明了在单一剂量水平比较利尿剂的研究的局限性。观察到的对数剂量反应曲线的外推为肾衰竭患者高剂量使用这些药物时报告的相对效能（布美他尼：呋塞米）为20:1提供了一种可能的解释。
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本文引用的文献
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Bioassay of diuretic agents in patients with congestive failure.充血性心力衰竭患者利尿剂的生物测定
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The problem of bioassay and comparative potency of diuretics. I. Parenteral and oral mercurial diuretics.利尿剂的生物测定和相对效价问题。I. 胃肠外和口服汞利尿剂。
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Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives.氨基苯甲酸类利尿剂。2. 4-取代-3-氨基-5-氨磺酰苯甲酸衍生物。
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Pharmacological properties of 3-n-butylamino-4-phenoxy-5-sulfamylbenzoic acid (Bumetanide), a new potent diuretic.新型强效利尿剂3-正丁氨基-4-苯氧基-5-氨磺酰苯甲酸（布美他尼）的药理特性
Arzneimittelforschung. 1972 Jan;22(1):66-72.
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Renal action, therapeutic use, and pharmacokinetics of the diuretic bumetanide.利尿剂布美他尼的肾脏作用、治疗用途及药代动力学
Clin Pharmacol Ther. 1974 Feb;15(2):141-55. doi: 10.1002/cpt1974152141.
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Bumetanide, a new potent diuretic. A clinical evaluation in congestive heart failure.布美他尼，一种新型强效利尿剂。充血性心力衰竭的临床评估。
Acta Med Scand. 1973 Jan-Feb;193(1-2):119-31.
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