Rabello-Gay M N, Ahmed A E
Mutat Res. 1980 Nov;79(3):249-55. doi: 10.1016/0165-1218(80)90072-5.
Acrylonitrile (VCN), a suspect human carcinogen, does not produce significant increases in cytogenetic aberrations in the mouse-bone marrow when given orally for 4, 15 or 30 days at doses equal to 7, 14 and 21 mg/kg/day resp. or by i.p. for the same time periods at doses of 10, 15 and 20 mg/kg/day. Rats treated orally with 16 daily doses of VCN (40 mg/kg/day) or potassium cyanide (KCN) (5 mg/kg/day) showed no increase of aberrant metaphases in the bone marrow over controls.
丙烯腈（VCN）是一种可疑的人类致癌物，当分别以7、14和21毫克/千克/天的剂量口服4天、15天或30天，或在相同时间段内以10、15和20毫克/千克/天的剂量腹腔注射时，在小鼠骨髓中不会导致细胞遗传学畸变显著增加。口服16剂VCN（40毫克/千克/天）或氰化钾（KCN）（5毫克/千克/天）的大鼠，其骨髓中异常中期细胞相较于对照组没有增加。
