Vis A, Folgering H
Respir Physiol. 1980 Nov;42(2):131-43. doi: 10.1016/0034-5687(80)90110-3.
The central chemoreceptors are excited by the composition of the interstitial fluid of the brainstem. The concentration of the constituents is influenced by the perfusion ratio in that area and the composition of the arterial blood, in articular PaCO2. We assessed the perfusion ratio in cats by measuring the blood flow in one vertebral artery and its dependence on changes in PETCO2. Our findings support the theory that CBF is controlled by extravascular pH during CO2-loading. The mean time constant for dilatation (tau = 339.2 s) was found to be considerably greater than the mean time constant for constriction (tau = 40.9 s). Neither time constant depends on the initial flow rate.
中枢化学感受器受脑干间质液成分的刺激。这些成分的浓度受该区域的灌注率以及动脉血成分（特别是动脉血二氧化碳分压）的影响。我们通过测量一条椎动脉的血流量及其对呼气末二氧化碳分压（PETCO2）变化的依赖性，评估了猫的灌注率。我们的研究结果支持这样一种理论，即在二氧化碳负荷期间，脑血流量（CBF）受血管外pH值的控制。发现扩张的平均时间常数（τ = 339.2秒）明显大于收缩的平均时间常数（τ = 40.9秒）。两个时间常数均不依赖于初始流速。
