肿瘤床的X线照射对肿瘤血流及血管对药物反应的影响
Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
作者信息
Jirtle R, Rankin J H, Clifton K H
出版信息
Br J Cancer. 1978 Jun;37(6):1033-8. doi: 10.1038/bjc.1978.150.
The blood flow of tumours growing in rat mammary glands previously exposed to 1500 R X-rays was 52% that of same-sized tumours in unirradiated host tissue. About 2 months after irradiation, the blood flow of the mammary gland was raised and that of the skin was unchanged, compared with the corresponding unirradiated tissue. Tumours growing in preirradiated and unirradiated mammary glands responded similarly to bolus injections of noradrenaline, angiotensin II, and isoprenaline. The responses of the irradiated tissues to these drugs were, however, not always the same as those of the corresponding unirradiated tissues. Exposure of the lungs to approximately 1500 R X-rays made the animals uniquely sensitive to bolus injections of noradrenaline and angiotensin II.
先前接受过1500伦琴X射线照射的大鼠乳腺中生长的肿瘤的血流量是未受照射宿主组织中相同大小肿瘤血流量的52%。与相应的未受照射组织相比，照射后约2个月，乳腺的血流量增加，而皮肤的血流量未发生变化。在预先照射和未照射的乳腺中生长的肿瘤对去甲肾上腺素、血管紧张素II和异丙肾上腺素的大剂量注射反应相似。然而，照射组织对这些药物的反应并不总是与相应的未照射组织相同。肺部接受约1500伦琴X射线照射后，动物对去甲肾上腺素和血管紧张素II的大剂量注射变得异常敏感。
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