水疱液中的酸性水解酶。4. 紫外线辐射的影响。

Acid hydrolases in blister fluid. 4. Influence of ultraviolet radiation.

作者信息

Volden G

出版信息

Br J Dermatol. 1978 Jul;99(1):53-60. doi: 10.1111/j.1365-2133.1978.tb01961.x.

DOI:10.1111/j.1365-2133.1978.tb01961.x

Abstract

Large, dose-related increases have been demonstrated in the activity of lysosomal hydrolases in the fluid of experimental suction blisters raised on skin previously irradiated with UVR-B. These increases appear after a latent period of 11--18 h, and the pattern of changes shows an extremely good correlation with the hydrolase profile of epidermis. These observations offer strong support for the concept that lysosomes participated in the sequence of events following UV irradiation, but seem to rule out the lysosome as the initial target for UVR.

摘要

在先前接受UVR-B照射的皮肤上产生的实验性抽吸水疱液中，溶酶体水解酶的活性已被证明与剂量相关地大幅增加。这些增加在11-18小时的潜伏期后出现，并且变化模式与表皮的水解酶谱显示出极好的相关性。这些观察结果为溶酶体参与紫外线照射后一系列事件的概念提供了有力支持，但似乎排除了溶酶体作为UVR的初始靶点。