Kumakiri M, Hashimoto K, Willis I
Br J Dermatol. 1978 Jul;99(1):65-75. doi: 10.1111/j.1365-2133.1978.tb01963.x.
Three white male volunteers were irradiated by long wave ultraviolet (UV-A) and by solar simulating radiation (SSR). An acute change of cutaneous nerves was found following a single exposure of UV-A irradiation. Non-myelinated Schwann cells and perineural cells in the papillary and reticular dermis were degenerated. Axoplasms appeared to be electron-dense, but were less affected than Schwann cells. After long-term repeated exposure, many free nerve endings were found in the dermo-epidermal junction above the basal lamina and some of them made a terminal enlargement. In one instance an axon made a swelling. Dermal free nerve endings also seemed to be increased in number and some of them were situated immediately beneath the melanocytes which were active in melanogenesis. Multiplication of basal lamina of the Schwann cells and perineural cells was observed. Amorphous material was precipitated around the non-myelinated Schwann cells. After a single exposure of SSR irradiation the degeneration of Schwann cells and axons in the dermo-epidermal junction was less severe than after UV-A and changes were minor in the reticular dermis. After repeated exposure, intra-epidermal proliferation of free nerve endings was detected. Dermal nerves were slightly affected. No intra-epidermal free nerve endings were observed in controls. The intra-epidermal proliferation of free nerve endings was confirmed following repeated UV exposures. Melanocyte-nerve association is suggested to be the cause of stimulating melanocyte activity.
三名白人男性志愿者接受了长波紫外线（UV-A）和太阳模拟辐射（SSR）照射。单次UV-A照射后发现皮肤神经出现急性变化。乳头层和网状真皮中的无髓施万细胞和神经周细胞发生退化。轴浆似乎电子密度增加，但受影响程度小于施万细胞。长期反复照射后，在基膜上方的真皮-表皮交界处发现许多游离神经末梢，其中一些末梢出现终末膨大。有一例轴突出现肿胀。真皮游离神经末梢数量似乎也增加了，其中一些紧邻正在进行黑素生成的黑素细胞下方。观察到施万细胞和神经周细胞的基膜增殖。无髓施万细胞周围有无定形物质沉淀。单次SSR照射后，真皮-表皮交界处施万细胞和轴突的退化程度比UV-A照射后轻，网状真皮中的变化较小。反复照射后，检测到游离神经末梢在表皮内增殖。真皮神经受影响轻微。对照组未观察到表皮内游离神经末梢。反复紫外线照射后证实了游离神经末梢在表皮内的增殖。黑素细胞与神经的关联被认为是刺激黑素细胞活性的原因。
