ICI 35868与硫喷妥钠对家兔呼吸作用的比较。

Comparison of the respiratory effects of ICI 35 868 and thiopentone in the rabbit.

作者信息

Bellman M H, Pleuvry B J

出版信息

Br J Anaesth. 1981 Apr;53(4):425-9. doi: 10.1093/bja/53.4.425.

DOI:10.1093/bja/53.4.425

Abstract

The effects of thiopentone and ICI 35 868 on minute volume, respiratory frequency, tidal volume and arterialized venous PCO2, pH and standard bicarbonate have been compared in the rabbit. ICI 35 868 has two to three times the potency of thiopentone, but equivalent anaesthetic doses cause similar decreases in minute volume. ICI 35 868 decreased tidal volume to a greater extent than thiopentone. Whilst the time courses of the two drugs were similar in most respects, thiopentone produced a more prolonged increase in PCO2. This was accompanied by an increase in standard bicarbonate which was not seen in rabbits treated with ICI 35 868.

摘要

在兔子身上比较了硫喷妥钠和ICI 35868对每分通气量、呼吸频率、潮气量以及动脉化静脉血的PCO₂、pH值和标准碳酸氢盐的影响。ICI 35868的效力是硫喷妥钠的两到三倍，但等效麻醉剂量会使每分通气量产生相似程度的降低。ICI 35868比硫喷妥钠更能降低潮气量。虽然两种药物在大多数方面的时间进程相似，但硫喷妥钠使PCO₂升高的时间更长。这伴随着标准碳酸氢盐的增加，而在接受ICI 35868治疗的兔子中未观察到这种情况。