二异丙基酚（ICI 35,868）与硫喷妥钠对躯体疼痛反应影响的比较

Comparison of the effect of diisopropyl phenol (ICI 35, 868) and thiopentone on response to somatic pain.

作者信息

Briggs L P, Dundee J W, Bahar M, Clarke R S

出版信息

Br J Anaesth. 1982 Mar;54(3):307-11. doi: 10.1093/bja/54.3.307.

DOI:10.1093/bja/54.3.307

Abstract

The response to somatic pain with sub-hypnotic doses of ICI 35, 868 (diisopropyl phenol in cremophor) and thiopentone was compared using tibial pressure algesimetry. Studies were also carried out following recovery from larger doses of both drugs. The patients underwent gynaecological procedures using only one of the two i.v. agents and nitrous oxide in oxygen. The studies confirmed the known antanalgesic action of thiopentone and demonstrated that diisopropyl phenol has an analgesic action which is an attractive feature in an i.v. anaesthetic agent.

摘要

使用胫骨压力测痛法比较了亚催眠剂量的ICI 35868（溶于聚氧乙烯蓖麻油的二异丙基苯酚）和硫喷妥钠对躯体疼痛的反应。还对两种药物大剂量给药后的恢复情况进行了研究。患者仅使用两种静脉注射药物之一以及氧化亚氮和氧气进行妇科手术。研究证实了硫喷妥钠已知的抗镇痛作用，并表明二异丙基苯酚具有镇痛作用，这在静脉麻醉剂中是一个吸引人的特性。