Milet C, Hillyard C J, Martelly E, Girgis S, Intyre I M, Lopez E
C R Seances Acad Sci D. 1980 Dec 8;291(12):977-80.
Extracts of the corpuscules of Stannius enhance Eel gill calcium efflux and increase bone resorption in the Rat. Thus the hormone is hypocalcaemic in the Eel although hypercalcaemic in the Rat. We show here that a 15 min. pulse perfusion of a synthetic fragment of human PTH 1-34 had a similar effect on gill calcium fluxes to that of CS extract. Further, we found that Eel plasma contains a substance reacting with five different antibodies against bovine PTH. The concentration of this plasma material is enhanced seven-fold by parenteral calcium and rendered extremely low or absent by CS removal. A convenient name for this major calcium-regulating hormone is parathyrine of the corpuscles of Stannius (PCS) since this reflects both its glandular source and chemical structure.
斯坦尼斯小体提取物可增强鳗鱼鳃的钙外流，并增加大鼠的骨吸收。因此，这种激素在鳗鱼中是降钙的，而在大鼠中是升钙的。我们在此表明，对人甲状旁腺激素1 - 34的合成片段进行15分钟的脉冲灌注，对鳃钙通量的影响与斯坦尼斯小体提取物相似。此外，我们发现鳗鱼血浆中含有一种能与五种不同的抗牛甲状旁腺激素抗体发生反应的物质。这种血浆物质的浓度通过肠外补钙可提高7倍，而通过去除斯坦尼斯小体则极低或消失。这种主要的钙调节激素的一个合适名称是斯坦尼斯小体甲状旁腺素（PCS），因为这既反映了其腺体来源，也反映了其化学结构。
