Pregnancy after prolonged pulsatile administration of luteinizing hormone-releasing hormone in a patient with clomiphene-resistant secondary amenorrhea.

Induction of ovulation with LRH, self-administered by the patient (20 microgram every 2 h, iv) from 0700-2300 h continuously for 90 days, is described. Three ovulatory cycles resulted, and the patient conceived during the third cycle. The morning serum LH and FSH concentrations showed a pattern similar to that seen in normal cycles. Total urinary estrogen and pregnanediol excretion did not differ from those in normal cycles. This observation shows that the described mode of treatment is feasible and can result in normal intrauterine pregnancy.