Altenburger W, Neumaier P S, Steinmetz M, Zachau H G
Nucleic Acids Res. 1981 Feb 25;9(4):971-81. doi: 10.1093/nar/9.4.971.
The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the upstream region were determined both in liver and in myeloma T DNA clones derived from the same mouse inbred strain. The sequences were identical, i.e. no somatic mutations were detected. Two sites in the region not coding for protein are discussed as possible targets of aberrant variable (V) gene translocations. Doublet frequencies were calculated in the approx. 2500 bp of the C region sequence reported in this paper and in the approx. 3400 bp of two rearranged V gene regions.
免疫球蛋白κ轻链的恒定（C；参考文献3）基因区段及其上下游约1 kb的区域已被测序。C基因区段本身以及上游区域部分的序列在来自同一近交系小鼠的肝脏和骨髓瘤T DNA克隆中均已测定。这些序列是相同的，即未检测到体细胞突变。该区域中两个不编码蛋白质的位点被讨论为异常可变（V）基因易位的可能靶点。本文报道的C区域序列约2500 bp以及两个重排V基因区域约3400 bp中的双峰频率已被计算。
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