苦马豆素（一种从灰苦马豆中分离出的吲哚里西啶生物碱）对溶酶体α-甘露糖苷酶的抑制作用。
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
作者信息
Dorling P R, Huxtable C R, Colegate S M
出版信息
Biochem J. 1980 Nov 1;191(2):649-51. doi: 10.1042/bj1910649.
Abstract
An indolizidine alkaloid (swainsonine) was isolated from the plant Swainsona canescens. Swainsonine is a specific and potent inhibitor of alpha-mannosidase (EC 3.2.1.24) and when administered to animals produces a phenocopy of the genetically based lysosomal storage disease, mannosidosis. Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
摘要
从灰绿苦马豆（Swainsona canescens）植物中分离出一种吲哚里西啶生物碱（苦马豆素）。苦马豆素是α-甘露糖苷酶（EC 3.2.1.24）的一种特异性强效抑制剂，给动物服用时会产生一种基于基因的溶酶体贮积病——甘露糖苷贮积症的拟表型。有证据表明苦马豆素是溶酶体α-甘露糖苷酶的一种可逆的活性位点导向抑制剂。
相似文献
1
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.苦马豆素（一种从灰苦马豆中分离出的吲哚里西啶生物碱）对溶酶体α-甘露糖苷酶的抑制作用。
Biochem J. 1980 Nov 1;191(2):649-51. doi: 10.1042/bj1910649.
2
Swainsonine, a potent mannosidase inhibitor, elevates rat liver and brain lysosomal alpha-D-mannosidase, decreases Golgi alpha-D-mannosidase II, and increases the plasma levels of several acid hydrolases.苦马豆素是一种有效的甘露糖苷酶抑制剂，它能提高大鼠肝脏和脑溶酶体α-D-甘露糖苷酶的活性，降低高尔基体α-D-甘露糖苷酶II的活性，并提高几种酸性水解酶的血浆水平。
Arch Biochem Biophys. 1983 Jul 15;224(2):594-600. doi: 10.1016/0003-9861(83)90247-3.
3
Marked differences in the swainsonine inhibition of rat liver lysosomal alpha-D-mannosidase, rat liver Golgi mannosidase II, and jack bean alpha-D-mannosidase.苦马豆素对大鼠肝脏溶酶体α-D-甘露糖苷酶、大鼠肝脏高尔基体甘露糖苷酶II和刀豆α-D-甘露糖苷酶的抑制作用存在显著差异。
Arch Biochem Biophys. 1985 Jan;236(1):427-34. doi: 10.1016/0003-9861(85)90643-5.
4
Production of the alkaloid swainsonine by a fungal endophyte in the host Swainsona canescens.内生真菌在宿主植物中产生苦马豆素。
J Nat Prod. 2013 Oct 25;76(10):1984-8. doi: 10.1021/np400274n. Epub 2013 Sep 20.
5
The uptake of swainsonine, a specific inhibitor of alpha-D-mannosidase, into normal human fibroblasts in culture.一种α-D-甘露糖苷酶的特异性抑制剂——苦马豆素在培养的正常人成纤维细胞中的摄取。
J Cell Biochem. 1983;21(2):107-17. doi: 10.1002/jcb.240210202.
6
7
The storage products in genetic and swainsonine-induced human mannosidosis.遗传性和苦马豆素诱导的人类甘露糖苷贮积症中的储存产物。
Biochem J. 1983 Dec 1;215(3):693-6. doi: 10.1042/bj2150693.
8
Lysosomal hydrolases in macrophages exposed to swainsonine.暴露于苦马豆素的巨噬细胞中的溶酶体水解酶。
Biochim Biophys Acta. 1983 Jul 14;762(4):569-76. doi: 10.1016/0167-4889(83)90061-7.
9
Swainsonine induces the production of hybrid glycoproteins and accumulation of oligosaccharides in male reproductive tissues of the rat.苦马豆素诱导大鼠雄性生殖组织中杂合糖蛋白的产生和寡糖的积累。
Biol Reprod. 1990 Jul;43(1):130-8. doi: 10.1095/biolreprod43.1.130.
10
Swainsonine inhibits macrophage receptor-mediated uptake and degradation of a mannosyl-oligosaccharide.苦马豆素抑制巨噬细胞受体介导的甘露糖基寡糖的摄取和降解。
Biochem Biophys Res Commun. 1983 Nov 15;116(3):922-30. doi: 10.1016/s0006-291x(83)80230-7.
引用本文的文献
1
Biosynthesis of the α-D-mannosidase inhibitor (-)-Swainsonine.α-D-甘露糖苷酶抑制剂（-）-苦马豆素的生物合成
Nat Chem Biol. 2025 Aug 11. doi: 10.1038/s41589-025-01997-y.
2
Fungal alkaloids mediate defense against bruchid beetles in field populations of an arborescent ipomoea.真菌生物碱介导了一种乔木状甘薯田间种群对豆象甲虫的防御。
J Chem Ecol. 2025 Feb 25;51(2):26. doi: 10.1007/s10886-025-01578-2.
3
Cyclic Imines and Their Salts as Universal Precursors in the Synthesis of Nitrogen-Containing Alkaloids.环状亚胺及其盐类作为含氮生物碱合成中的通用前体。
Int J Mol Sci. 2024 Dec 31;26(1):288. doi: 10.3390/ijms26010288.
4
The Effects of Gene Function of Endophytic Fungus OW 7.8 on Its Swainsonine Biosynthesis.内生真菌OW 7.8基因功能对其苦马豆素生物合成的影响
Microorganisms. 2024 Oct 17;12(10):2081. doi: 10.3390/microorganisms12102081.
5
The Effects of Gene Function of Endophytic Fungus OW 7.8 on Its Swainsonine Biosynthesis.内生真菌 OW7.8 的基因功能对其苦马豆素生物合成的影响。
Int J Mol Sci. 2024 Sep 25;25(19):10310. doi: 10.3390/ijms251910310.
6
Lisosomal storage disease caused by ingestion of Astragalus spp in llamas: an emergent concern.因摄入驴豆类植物而导致的溶酶体贮积症：一个新出现的关注点。
Vet Res Commun. 2024 Aug;48(4):1999-2005. doi: 10.1007/s11259-024-10397-x. Epub 2024 May 17.
7
Analysis of the Mycotoxin Levels and Expression Pattern of SWN Genes at Different Time Points in the Fungus .真菌中不同时间点霉菌毒素水平及SWN基因表达模式的分析
Microorganisms. 2024 Mar 27;12(4):670. doi: 10.3390/microorganisms12040670.
8
Alternaria gansuense, a Plant Systematic Fungal Pathogen Producing Swainsonine in Vivo and in Vitro.甘肃链格孢，一种植物系统真菌病原体，在体内和体外均可产生苦马豆素。
Curr Microbiol. 2023 Jun 1;80(7):232. doi: 10.1007/s00284-023-03341-w.
9
Identification of global inhibitors of cellular glycosylation.鉴定细胞糖基化的全球抑制剂。
Nat Commun. 2023 Feb 20;14(1):948. doi: 10.1038/s41467-023-36598-7.
10
1,4-Dideoxy-1,4-imino-D- and L-lyxitol-based inhibitors bind to Golgi α-mannosidase II in different protonation forms.基于 1,4-二脱氧-1,4-亚氨基-D-和 L-山梨醇的抑制剂以不同的质子化形式结合到高尔基 α-甘露糖苷酶 II 上。
Org Biomol Chem. 2022 Nov 23;20(45):8932-8943. doi: 10.1039/d2ob01545e.
本文引用的文献
1
On the inhibition of beta-N-acetyl-D-glucosaminidase by 2-acetamido-2-deoxy-D-glucono-(1-5)-lactone.关于2-乙酰氨基-2-脱氧-D-葡萄糖酸-(1-5)-内酯对β-N-乙酰-D-氨基葡萄糖苷酶的抑制作用
Biochem Biophys Res Commun. 1968 Sep 30;32(6):1025-30. doi: 10.1016/0006-291x(68)90132-0.
2
Human liver alpha-D-mannosidase activity.人肝脏α-D-甘露糖苷酶活性。
Clin Chim Acta. 1974 Aug 30;55(1):11-9. doi: 10.1016/0009-8981(74)90328-3.
3
Active site directed effectors of allosteric enzymes.别构酶的活性位点导向效应物。
Biochim Biophys Acta. 1975 Jan 23;377(1):197-202. doi: 10.1016/0005-2744(75)90300-9.
4
Characterization of human liver alpha-D-mannosidase purified by affinity chromatography.通过亲和层析纯化的人肝脏α-D-甘露糖苷酶的特性分析。
Biochem J. 1976 Mar 1;153(3):579-87. doi: 10.1042/bj1530579.
5
Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.斯温氏豆属中毒中的溶酶体储存：一种诱导性甘露糖苷贮积症。
Neuropathol Appl Neurobiol. 1978 Jul-Aug;4(4):285-95. doi: 10.1111/j.1365-2990.1978.tb00547.x.
Zotero 插件