Smolobochkin Andrey, Gazizov Almir, Sidlyaruk Nikita, Akylbekov Nurgali, Zhapparbergenov Rakhmetulla, Burilov Alexander
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
Laboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Aiteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.
Int J Mol Sci. 2024 Dec 31;26(1):288. doi: 10.3390/ijms26010288.
Alkaloids are predominantly nitrogen-containing heterocyclic compounds that are usually isolated from plants, and sometimes from insects or animals. Alkaloids are one of the most important types of natural products due to their diverse biological activities and potential applications in modern medicine. Cyclic imines were chosen as starting compounds for the synthesis of alkaloids due to their high synthetic potential. Thus, this review summarizes the achievements in the synthesis of various alkaloids from cyclic imines, paying special attention to stereoselective methods used for their preparation. Information on the biological activity of some alkaloids, their application and occurrence in natural objects is presented. Synthesis methods are classified based on the type of alkaloid obtained.
生物碱主要是含氮杂环化合物，通常从植物中分离得到，有时也从昆虫或动物中分离得到。由于其多样的生物活性和在现代医学中的潜在应用，生物碱是最重要的天然产物类型之一。由于其高合成潜力，环状亚胺被选作生物碱合成的起始化合物。因此，本综述总结了从环状亚胺合成各种生物碱的研究成果，特别关注用于其制备的立体选择性方法。还介绍了一些生物碱的生物活性、它们在天然物质中的应用和存在情况。合成方法根据所得生物碱的类型进行分类。
