内毒素对大鼠肺组织前列腺素释放的体内和体外作用
In vivo and in vitro effects of endotoxin on prostaglandin release from rat lung.
作者信息
Feuerstein N, Ramwell P W
出版信息
Br J Pharmacol. 1981 Jun;73(2):511-6. doi: 10.1111/j.1476-5381.1981.tb10450.x.
Abstract
1 The release of prostaglandins (PGE2, PGF2 alpha, PGI2) and thromboxane A2 (TxA2) from rat lung exposed to E. coli endotoxin, in vivo or in vitro has been studied. 2 Lung strips of endotoxin-treated rats demonstrated a preferential increase of TxA2 and PGF2 alpha and a decrease in the ratio PGI2/TxA2. 3 These data suggest that changes in the proportions of arachidonic acid metabolites might play a role in the pulmonary pathophysiology during endotoxin shock. 4 Incubation of lung strips with endotoxin in vitro failed to stimulate prostaglandin release; paradoxically, it suppressed both the spontaneous and the ionophore-induced prostaglandin release. 5 These findings suggest that the increase in prostaglandin release by the lung following endotoxin administration in vivo is probably mediated by factor(s) generated in endotoxaemia and is not due to a direct action of endotoxin on the lung tissue.
摘要
- 已经研究了在体内或体外暴露于大肠杆菌内毒素的大鼠肺中前列腺素（PGE2、PGF2α、PGI2）和血栓素A2（TxA2）的释放情况。2. 经内毒素处理的大鼠的肺条显示TxA2和PGF2α优先增加，且PGI2/TxA2比值降低。3. 这些数据表明，花生四烯酸代谢产物比例的变化可能在内毒素休克期间的肺部病理生理学中起作用。4. 体外将肺条与内毒素一起孵育未能刺激前列腺素释放；矛盾的是，它抑制了自发的和离子载体诱导的前列腺素释放。5. 这些发现表明，体内给予内毒素后肺中前列腺素释放的增加可能是由内毒素血症中产生的因子介导的，而不是由于内毒素对肺组织的直接作用。
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