Miettinen T A, Huttunen J K, Kuusi T, Kumlin T, Mattila S, Naukkarinen V, Strandberg T
Clin Chim Acta. 1981 Jun 2;113(1):59-64. doi: 10.1016/0009-8981(81)90440-x.
The effect of discontinuation of long term (34-56 months) probucol treatment on serum lipids, lipoproteins and on the activity of postheparin plasma lipoprotein and hepatic lipase ahs been studied in 10 healthy males participating in a primary prevention programme of coronary heart disease. A significant increase was observed in the activity of postheparin plasma lipoprotein lipase, in the total serum cholesterol concentration and in the serum concentrations of high density lipoprotein (HDL) cholesterol, HDL phospholipids and apoprotein AI after withdrawal of the drug No changes were seen in the serum triglyceride levels or in the activity of postheparin plasma hepatic lipase. The activity of postheparin plasma hepatic lipase tended to correlate with the serum concentration of HDL. No correlations were present between the individual changes in the serum levels of HDL and in the activity of postheparin plasma triglyceride lipases.
在10名参与冠心病一级预防项目的健康男性中，研究了长期（34 - 56个月）普罗布考治疗中断对血清脂质、脂蛋白以及肝素后血浆脂蛋白和肝脂酶活性的影响。停药后，观察到肝素后血浆脂蛋白脂酶活性、总血清胆固醇浓度以及高密度脂蛋白（HDL）胆固醇、HDL磷脂和载脂蛋白AI的血清浓度显著增加。血清甘油三酯水平或肝素后血浆肝脂酶活性未见变化。肝素后血浆肝脂酶活性倾向于与HDL的血清浓度相关。HDL血清水平的个体变化与肝素后血浆甘油三酯脂酶活性之间不存在相关性。
