Ehnholm C, Aho K, Huttunen J K, Kostiainen E, Mattila K, Pakkarainen J, Cantell K
Arteriosclerosis. 1982 Jan-Feb;2(1):68-73. doi: 10.1161/01.atv.2.1.68.
The effect of interferon administration on the concentration of plasma lipoproteins and on the activity of postheparin plasma lipoprotein lipase and hepatic lipase was studied in six healthy men. Daily injection of human leukocyte interferon for 1 week lowered the plasma level of total cholesterol, very low density lipoprotein + low density lipoprotein cholesterol, high density lipoprotein cholesterol, and apolipoprotein A-1 in all subjects. Simultaneously, the activity of postheparin plasma hepatic lipase and lipoprotein lipase decreased by 20% to 50%. These observations may be of importance in the interpretation of lipoprotein changes seen in acute and chronic infections and should be borne in mind when prolonged treatment with interferon is considered.
在六名健康男性中研究了给予干扰素对血浆脂蛋白浓度以及肝素后血浆脂蛋白脂肪酶和肝脂肪酶活性的影响。每日注射人白细胞干扰素，持续1周，结果发现所有受试者的血浆总胆固醇、极低密度脂蛋白+低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和载脂蛋白A-1水平均降低。同时，肝素后血浆肝脂肪酶和脂蛋白脂肪酶的活性降低了20%至50%。这些观察结果对于解释急慢性感染时出现的脂蛋白变化可能具有重要意义，在考虑干扰素的长期治疗时应予以铭记。
