Gentile J M, Hyde K, Schubert J
Toxicol Lett. 1981 Mar;7(6):439-48. doi: 10.1016/0378-4274(81)90090-4.
Conclusions as to the mutagenicity and carcinogenicity of metal salts can be ambiguous and misleading, especially for metal ions having a high charge/radius ratio, hence a strong tendency to hydrolyze. Using the rec-assay, we determined whether the mutagenicity of chromium salts was reduced by complexation, as in the case of Cr(VI), or induced in the case of Cr(III). We find that several chelants, in proportion to concentration, reduce or eliminate the mutagenicity of Cr2O32-. These include EDTA, salicylate (SA), and Tiron (disodium 1,2-dihydroxylbenzene-3,5-disulfonate). Cr(III) was rendered slightly mutagenic by salicylate and citrate. None of the chelating agents or their combinations were mutagenic.
关于金属盐的致突变性和致癌性的结论可能含混不清且具有误导性，尤其是对于那些具有高电荷/半径比、因而有强烈水解倾向的金属离子。使用重组检测法，我们确定了铬盐的致突变性是否像六价铬那样通过络合作用而降低，或者像三价铬那样被诱导产生。我们发现，几种螯合剂按浓度比例可降低或消除三氧化二铬的致突变性。这些螯合剂包括乙二胺四乙酸（EDTA）、水杨酸盐（SA）和钛铁试剂（1,2 - 二羟基苯 - 3,5 - 二磺酸钠）。水杨酸盐和柠檬酸盐使三价铬具有轻微的致突变性。没有一种螯合剂或其组合具有致突变性。
