Dubois P J, Drayer B P, Sage M, Osborne D, Heinz E R
AJNR Am J Neuroradiol. 1981 Jul-Aug;2(4):313-7.
Metrizamide computed tomography (CT) myelography is clinically useful in the detection of syringohydromyelia. The mechanism by which intrathecally injected metrizamide migrates into the intramedullary cavity is unknown, although reflux into the central canal of the cord via the obex has been postulated. Since intrathecally injected metrizamide has been shown to penetrate normal brain, similar penetrance of the spinal cord might be expected. Five anesthetized mongrel dogs were examined with sequential CT scanning of the cervical spine for 24 hr after intrathecal introduction of metrizamide. The attenuation values of the specified subarachnoid space and the spinal cord at the level of the atlantoaxial joint were recorded. A significant and reproducible increase with time in attenuation values within the cervical spinal cord accompanied by a progressive decrease in attenuation values of the subarachnoid space was observed. The proposed mechanism of cord enhancement, the implication for cord imaging, and the analysis of patients with syringohydromyelia are discussed.
甲泛葡胺计算机断层扫描（CT）脊髓造影在检测脊髓空洞症方面具有临床实用性。鞘内注射的甲泛葡胺迁移至髓内腔的机制尚不清楚，尽管有人推测其可能通过闩部反流至脊髓中央管。由于已证明鞘内注射的甲泛葡胺可穿透正常脑实质，因此预计其对脊髓也有类似的穿透性。对5只麻醉的杂种犬在鞘内注入甲泛葡胺后连续24小时进行颈椎CT扫描检查。记录寰枢关节水平特定蛛网膜下腔和脊髓的衰减值。观察到颈髓内衰减值随时间显著且可重复增加，同时蛛网膜下腔衰减值逐渐降低。文中讨论了脊髓强化的推测机制、对脊髓成像的意义以及对脊髓空洞症患者的分析。
