Mattsson R, Mattsson A, Kihlström J E, Lindahl-Kiessling K
Arch Environ Contam Toxicol. 1981;10(3):281-8. doi: 10.1007/BF01055629.
Syngeneically and allogeneically mated CBA mice were daily given orally either pure peanut oil or peanut oil containing 0.5 mg 2,2', 4,4', 5,5'-hexachlorobiphenyl (HCB) beginning at the day of implantation. The mice were dissected on day 12 and 18 of gestation when the weight of thymus, spleen, and liver were recorded. The spontaneous mitotic activity of spleen cells was evaluated in vitro, and the number of resorbed foetuses was recorded. Neither spleen weight nor thymus weight was altered, but the liver weight was significantly increased by HCB treatment. The spontaneous mitotic activity of spleen cells did not differ significantly between HCB-treated and control mice. The frequency of resorbed foetuses was not increased by HCB treatment either in syngeneically or allogeneically mated mice, but it was observed that mice fed HCB were less sensitive to environmental disturbance than control mice.
从植入当天开始，将同基因和异基因交配的CBA小鼠每天口服给予纯花生油或含有0.5毫克2,2',4,4',5,5'-六氯联苯（HCB）的花生油。在妊娠第12天和第18天解剖小鼠，记录胸腺、脾脏和肝脏的重量。体外评估脾细胞的自发有丝分裂活性，并记录吸收胎儿的数量。HCB处理对脾脏重量和胸腺重量均无影响，但肝脏重量显著增加。HCB处理组和对照组小鼠脾细胞的自发有丝分裂活性无显著差异。在同基因和异基因交配的小鼠中，HCB处理均未增加吸收胎儿的频率，但观察到喂食HCB的小鼠对环境干扰的敏感性低于对照小鼠。
