Jardim E, Takayanagui O M
Arq Neuropsiquiatr. 1981 Mar;39(1):32-41. doi: 10.1590/s0004-282x1981000100004.
The epileptic syndrome in chronic Chagas' disease is rarely reported in neurological literature. At the present time many papers have demonstrated that histopathological basis of Chagas' disease is a neuronal destruction. The authors studied 167 epileptic patients; 44 out of them had a chronic form of the disease. It was made a comparison of semiologic data between the two groups, and also the evaluation of the therapeutic results with anticonvulsant drugs. The chagasic patients had the onset of epileptic seizures later than the control group, with great predominance of partial seizures of autonomic type. The neurologic examination and cerebrospinal fluid test revealed moderate rates of disturbances, but not sufficient to characterize a neurologic syndrome. The EEG study was performed in 15 of the 44 cases and revealed a suggestive pattern of a diffuse cerebral damage in half of patients. Anticonvulsant therapy based on use of phenylhydantoin, barbituric acid derivates, primidone and benzodiazepines, showed that control of epileptic seizures in Chagas' diseases is more difficult and requires greater quantities of drugs than in the control group.
慢性恰加斯病中的癫痫综合征在神经学文献中鲜有报道。目前，许多论文已证明恰加斯病的组织病理学基础是神经元破坏。作者研究了167例癫痫患者，其中44例患有该病的慢性形式。对两组患者的症状学数据进行了比较，并评估了抗惊厥药物的治疗效果。患恰加斯病的患者癫痫发作的起始时间晚于对照组，自主神经型部分性发作占主导。神经学检查和脑脊液检查显示有中度紊乱率，但不足以确诊一种神经综合征。对44例患者中的15例进行了脑电图研究，结果显示一半患者有弥漫性脑损伤的提示性模式。基于苯妥英、巴比妥酸衍生物、扑米酮和苯二氮䓬类药物的抗惊厥治疗表明，与对照组相比，控制恰加斯病中的癫痫发作更困难，需要更多的药物。
