Chaĭka L A, Pankov E Ia
Farmakol Toksikol. 1981 Jan-Feb;44(1):74-7.
A study was made on the mechanism of action of the antivaricose agent tribenol (ethyl-3,5,6-tri-O-benzyl-D-glucofuranozide; glivenol) on the activity of hydroxyreductase on the Krebs cycle and glycolysis during occlusion of the femoral vein and its inflammation in rats. It was shown histochemically that on the 5th day of traumatic phlebitis after ligation of the vein, its wall shows a substantial rise in the activity of succinate- and malate dehydrogenase (SDH and MDH), a slight increase in the activity of lactate dehydrogenase (LDH) and a pronounced lowering of the activity of alpha-glycerophosphate dehydrogenase (alpha-GPDH). The treatment with tribenol in a dose of 25 mg/kg for 5 days makes the activity of SDH and alpha-GPDH return to normal, drastically increases the activity of LDH and produces no significant effect on MDH. In a dose of 250 mg/kg tribenol makes the activity of all hydroxyreductases studied return to normal or reduces it.
研究了抗静脉曲张药物曲苄醇（乙基-3,5,6-三-O-苄基-D-葡萄糖呋喃糖苷；利脉诺）对大鼠股静脉闭塞及其炎症过程中克雷布斯循环和糖酵解中羟还原酶活性的作用机制。组织化学显示，在静脉结扎后的创伤性静脉炎第5天，静脉壁琥珀酸脱氢酶和苹果酸脱氢酶（SDH和MDH）的活性大幅升高，乳酸脱氢酶（LDH）的活性略有增加，而α-甘油磷酸脱氢酶（α-GPDH）的活性显著降低。以25mg/kg的剂量给予曲苄醇治疗5天，可使SDH和α-GPDH的活性恢复正常，显著增加LDH的活性，而对MDH无显著影响。以250mg/kg的剂量给予曲苄醇，可使所有研究的羟还原酶的活性恢复正常或降低。
