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1
Precise mapping of the homothallism genes HML and HMR in Saccharomyces cerevisiae.酿酒酵母中同宗配合基因HML和HMR的精确图谱绘制。
Genetics. 1980 Oct;96(2):315-20. doi: 10.1093/genetics/96.2.315.
2
Mechanism of MAT alpha donor preference during mating-type switching of Saccharomyces cerevisiae.酿酒酵母交配型转换过程中MATα供体偏好的机制。
Mol Cell Biol. 1996 Feb;16(2):657-68. doi: 10.1128/MCB.16.2.657.
3
Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeast.酵母中交配型基因转座过程中转座序列与替代序列之间存在物理相互作用的证据。
Cell. 1980 Nov;22(1 Pt 1):291-8. doi: 10.1016/0092-8674(80)90176-2.
4
MATa donor preference in yeast mating-type switching: activation of a large chromosomal region for recombination.酵母交配型转换中MATa供体偏好：用于重组的大染色体区域的激活
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5
Directionality of yeast mating-type interconversion.酵母交配型相互转换的方向性。
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6
Structure and organization of transposable mating type cassettes in Saccharomyces yeasts.酿酒酵母中转座交配型盒的结构与组织
Proc Natl Acad Sci U S A. 1980 May;77(5):2839-43. doi: 10.1073/pnas.77.5.2839.
7
Efficient production of a ring derivative of chromosome III by the mating-type switching mechanism in Saccharomyces cerevisiae.通过酿酒酵母中的交配型转换机制高效生产III号染色体的环状衍生物。
Mol Cell Biol. 1983 May;3(5):803-10. doi: 10.1128/mcb.3.5.803-810.1983.
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The structure of transposable yeast mating type loci.可转座酵母交配型基因座的结构。
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9
Transposition of yeast mating type genes from two translocations of the left arm of chromosome III.酵母交配型基因在第三条染色体左臂的两次易位中的转位。
Mol Cell Biol. 1981 Dec;1(12):1106-19. doi: 10.1128/mcb.1.12.1106-1119.1981.
10
Rules of donor preference in saccharomyces mating-type gene switching revealed by a competition assay involving two types of recombination.通过涉及两种重组类型的竞争试验揭示酿酒酵母交配型基因转换中供体偏好规则。
Genetics. 1997 Oct;147(2):399-407. doi: 10.1093/genetics/147.2.399.

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1
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Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays.严格的交配型调控的营养缺陷型增加了与酿酒酵母突变体阵列进行系统遗传相互作用筛选的准确性。
Genetics. 2009 Jan;181(1):289-300. doi: 10.1534/genetics.108.092981. Epub 2008 Oct 28.
3
Three mating type-like loci in Candida glabrata.光滑念珠菌中的三个交配型样位点。
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4
X-ray enhances mating type switching in heterothallic strains of Saccharomyces cerevisiae.X射线增强酿酒酵母异宗配合菌株中的交配型转换。
Mol Gen Genet. 1982;186(4):512-7. doi: 10.1007/BF00337958.
5
Efficient production of a ring derivative of chromosome III by the mating-type switching mechanism in Saccharomyces cerevisiae.通过酿酒酵母中的交配型转换机制高效生产III号染色体的环状衍生物。
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Rearrangements of the transposable mating-type cassettes of fission yeast.裂殖酵母可转座交配型盒式结构的重排。
EMBO J. 1984 Mar;3(3):603-10. doi: 10.1002/j.1460-2075.1984.tb01855.x.
7
Mating type control in Saccharomyces cerevisiae: a frameshift mutation at the common DNA sequence, X, of the HML alpha locus.酿酒酵母中的交配型控制：HMLα基因座常见DNA序列X处的移码突变。
Mol Cell Biol. 1984 Jan;4(1):203-11. doi: 10.1128/mcb.4.1.203-211.1984.
8
Transposition of yeast mating type genes from two translocations of the left arm of chromosome III.酵母交配型基因在第三条染色体左臂的两次易位中的转位。
Mol Cell Biol. 1981 Dec;1(12):1106-19. doi: 10.1128/mcb.1.12.1106-1119.1981.
9
The Saccharomyces cerevisiae chromosome III left telomere has a type X, but not a type Y', ARS region.酿酒酵母III号染色体左端粒有一个X型而非Y'型自主复制序列（ARS）区域。
Mol Cell Biol. 1986 Apr;6(4):1352-6. doi: 10.1128/mcb.6.4.1352-1356.1986.
10
The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae.sum1-1突变影响酿酒酵母中沉默交配型基因的转录。
Mol Cell Biol. 1990 Jan;10(1):409-12. doi: 10.1128/mcb.10.1.409-412.1990.

本文引用的文献

1
MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE.酿酒酵母中 HMa 和 HMalpha 基因座的 MAR1 调节因子。
Genetics. 1979 Sep;93(1):37-50. doi: 10.1093/genetics/93.1.37.
2
Heterogeneity of Clones of Saccharomyces Derived from Haploid Ascospores.源自单倍体子囊孢子的酿酒酵母克隆的异质性。
Proc Natl Acad Sci U S A. 1953 Mar;39(3):171-9. doi: 10.1073/pnas.39.3.171.
3
A mutation that permits the expression of normally silent copies of mating-type information in Saccharomyces cerevisiae.一种能使酿酒酵母中通常沉默的交配型信息拷贝得以表达的突变。
Genetics. 1979 Sep;93(1):13-35. doi: 10.1093/genetics/93.1.13.
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Control of yeast cell types by mobile genes: a test.通过移动基因控制酵母细胞类型：一项测试
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5264-8. doi: 10.1073/pnas.76.10.5264.
5
A DELETION IN YEAST AND ITS BEARING ON THE STRUCTURE OF THE MATING TYPE LOCUS.酵母中的一个缺失及其与交配型基因座结构的关系。
Genetics. 1963 Dec;48(12):1727-9. doi: 10.1093/genetics/48.12.1727.
6
Interconversion of yeast cell types by transposable genes.通过转座基因实现酵母细胞类型的相互转换。
Genetics. 1980 Jul;95(3):631-48. doi: 10.1093/genetics/95.3.631.
7
Structure and organization of transposable mating type cassettes in Saccharomyces yeasts.酿酒酵母中转座交配型盒的结构与组织
Proc Natl Acad Sci U S A. 1980 May;77(5):2839-43. doi: 10.1073/pnas.77.5.2839.
8
The structure of transposable yeast mating type loci.可转座酵母交配型基因座的结构。
Cell. 1980 Mar;19(3):753-64. doi: 10.1016/s0092-8674(80)80051-1.
9
Mating types in Saccharomyces: their convertibility and homothallism.酿酒酵母中的交配型：它们的可转换性与同宗配合现象。
Genetics. 1971 Mar;67(3):327-35. doi: 10.1093/genetics/67.3.327.
10
[Genetic control of sensitivity of mammalian cells to the lethal and mutagenic action of ultraviolet rays].[哺乳动物细胞对紫外线致死和诱变作用敏感性的遗传控制]
Genetika. 1973 Nov;9(11):82-9.

酿酒酵母中同宗配合基因HML和HMR的精确图谱绘制。

Precise mapping of the homothallism genes HML and HMR in Saccharomyces cerevisiae.

作者信息

Klar A J, McIndoo J, Hicks J B, Strathern J N

出版信息

Genetics. 1980 Oct;96(2):315-20. doi: 10.1093/genetics/96.2.315.

DOI:10.1093/genetics/96.2.315
PMID:6790330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1214301/
Abstract

The HML and HMR loci carry unexpressed copies of MATa and MAT alpha information, and a replica of that information is transposed to MAT during mating-type interchange in Saccharomyces yeasts. A negative control mechanism keeps silent the information located at the HML and HMR loci. We mapped these loci by constructing strains in which these loci are expressed. In these strains, the mating type of the segregants is dependent upon the allele at HML and HMR. This novel approach is independent of their switching function. HML is located on the left arm of chromosome III distal to his4 by about 26.8 centimorgans (cM). HMR maps on the right arm of the same chromosome distal to thr4 by about 39.8 cM and proximal to MAL2 by about 1.0 cM. The results allow the exact placement of these loci and are in accord with the observations made by Harashima and Oshima (1976).

摘要

HML和HMR位点携带MATa和MATα信息的未表达拷贝，在酿酒酵母交配型转换过程中，该信息的一个副本会转移到MAT位点。一种负调控机制使位于HML和HMR位点的信息保持沉默。我们通过构建使这些位点表达的菌株来对这些位点进行定位。在这些菌株中，分离株的交配型取决于HML和HMR位点的等位基因。这种新方法独立于它们的转换功能。HML位于第三条染色体左臂上，距离his4约26.8厘摩（cM）。HMR位于同一条染色体右臂上，距离thr4约39.8 cM，距离MAL2约1.0 cM。这些结果确定了这些位点的确切位置，与原岛和大岛（1976年）的观察结果一致。