延髓表面化学感受器对心血管的控制

Cardiovascular control by medullary surface chemoreceptors.

作者信息

Lioy F, Hanna B D, Polosa C

出版信息

J Auton Nerv Syst. 1981 Feb;3(1):1-7. doi: 10.1016/0165-1838(81)90025-4.

Abstract

The cardiovascular and respiratory effects of superfusion of the ventral surface of the medulla with acid hypercapnic or alkaline hypocapnic solutions have been studied in anaesthetized, paralyzed, artificially ventilated cats. Peripheral chemoreceptor and baroreceptor denervation was achieved by section of carotid sinus, aortic and cervical vagus nerves. Systemic arterial and central venous pressure, hindquarters blood flow, heart rate and phrenic nerve activity were recorded. Acid hypercapnic (pH 6.8, pCO2 85 mm Hg) superfusion caused increases in systemic arterial pressure, phrenic nerve activity and heart rate, and a decrease in hindquarters blood flow. Alkaline hypocapnic (pH u.i, pCO2 less than 10 mmHg) superfusion caused opposite effects. These experiments indicate a significant role of the chemoreceptors of the ventral surface of the medulla in cardiovascular control.

摘要

在麻醉、麻痹并进行人工通气的猫身上，研究了用酸性高碳酸血症或碱性低碳酸血症溶液灌注延髓腹侧面的心血管和呼吸效应。通过切断颈动脉窦、主动脉和颈迷走神经来实现外周化学感受器和压力感受器去神经支配。记录全身动脉压、中心静脉压、后肢血流量、心率和膈神经活动。酸性高碳酸血症（pH 6.8，pCO2 85 mmHg）灌注导致全身动脉压、膈神经活动和心率增加，后肢血流量减少。碱性低碳酸血症（pH 7.1，pCO2小于10 mmHg）灌注产生相反的效应。这些实验表明延髓腹侧面化学感受器在心血管控制中起重要作用。