Millhorn D E, Eldridge F L, Waldrop T G
Respir Physiol. 1982 Jul;49(1):23-39. doi: 10.1016/0034-5687(82)90101-3.
The effect on respiration, as measured by phrenic nerve activity, of bilateral graded cooling of the intermediate, or I(s), areas of the ventral medulla was determined in anesthetized, vagotomized, glomectomized and paralyzed cats. In addition the effect of cooling the I(s) areas on the responses to central and peripheral chemoreceptor afferent test stimuli were studied. When end-tidal PCO2 was kept constant, graded cooling of the I(s) areas led to graded reductions of phrenic activity and arterial pressure. Furthermore, the respiratory response to test stimuli (carotid sinus nerve or CO2) was decreased progressively during graded cooling of the I(s) areas from 40 degrees C to 20 degrees C. We conclude that area I(s) is part of a common pathway for afferent input from both the central and peripheral chemoreceptors and that it is involved in the initial integration of both inputs.
在麻醉、切断迷走神经、切除肾小球旁器并使其瘫痪的猫身上，测定了延髓腹侧中间区即I(s)区双侧分级冷却对呼吸（通过膈神经活动来衡量）的影响。此外，还研究了冷却I(s)区对中枢和外周化学感受器传入测试刺激反应的影响。当呼气末二氧化碳分压保持恒定时，I(s)区的分级冷却导致膈神经活动和动脉血压的分级降低。此外，在I(s)区从40℃分级冷却至20℃的过程中，对测试刺激（颈动脉窦神经或二氧化碳）的呼吸反应逐渐降低。我们得出结论，I(s)区是中枢和外周化学感受器传入输入的共同通路的一部分，并且它参与了这两种输入的初始整合。
