Miyamura M, Fujitsuka N, Matsui H
Jpn J Physiol. 1980;30(6):945-53. doi: 10.2170/jjphysiol.30.945.
The ventilatory response to carbon dioxide at rest was determined repeatedly by the rebreathing method; three successive CO2 response lines, with 30-min intervals, were examined in 12 healthy male subjects. Overall mean slopes obtained at 30, 60 and 90 min were 2.95, 2.47 and 2.28 liters/min . mmHg, respectively, the difference being statistically not significant. However, the slopes of four high responders, who were subjects with higher slopes than that of the mean values obtained here, decreased significantly (p less than 0.05) at 60 min as compared with the 30 min test, but this did not occur in the other subjects. Better reproducibility in obtaining the CO2 response slopes in the high responders was observed in the first rather than the 60 or 90 min trails, suggesting incomplete recovery in the humoral agents released during the CO2 test. These results indicated that the CO2 response curve by rebreathing should be determined carefully, especially in the high responder, taking into consideration its individual variability and and interval in consecutive measurements.
通过重复呼吸法反复测定静息状态下对二氧化碳的通气反应；在12名健康男性受试者中，每隔30分钟检查连续三条二氧化碳反应曲线。在30、60和90分钟时获得的总体平均斜率分别为2.95、2.47和2.28升/分钟·毫米汞柱，差异无统计学意义。然而，四名高反应者（即斜率高于此处获得的平均值的受试者）的斜率在60分钟时与30分钟测试相比显著下降（p<0.05），但其他受试者未出现这种情况。在高反应者中，在第一次试验而非60或90分钟试验中观察到获得二氧化碳反应斜率的重复性更好，这表明在二氧化碳测试期间释放的体液因子恢复不完全。这些结果表明，通过重复呼吸法测定二氧化碳反应曲线时应谨慎，尤其是在高反应者中，要考虑到其个体变异性和连续测量的间隔时间。
