Highton J, Panayi G S, Griffin J
Agents Actions. 1980 Dec;10(6):507-8. doi: 10.1007/BF02024152.
Peripheral blood lymphocyte mitogen responsiveness was studied in 21 patients with rheumatoid arthritis being treated with sodium aurothiomalate. There was a significant increase in lymphocyte response to concanavalin A and pokeweed mitogen but not to phytohaemagglutinin. This observed increase in lymphocyte response contrasts with the suppressive effect of gold salts in vitro. We propose that this apparent contradiction may be explained by the relatively low serum gold levels measured in our patients, compared with expected levels in synovial membrane. Thus gold could suppress rheumatoid inflammation in the "target tissue" while having little suppressive action in the peripheral blood compartment, where a removal of suppressive influences due to active disease might then be seen as a net improvement in lymphocyte responsiveness.
对21例正在接受硫代苹果酸金钠治疗的类风湿性关节炎患者的外周血淋巴细胞有丝分裂原反应性进行了研究。淋巴细胞对刀豆球蛋白A和商陆有丝分裂原的反应显著增加，但对植物血凝素的反应未增加。观察到的淋巴细胞反应增加与金盐在体外的抑制作用形成对比。我们认为，与滑膜中预期水平相比，我们患者中测得的血清金水平相对较低，这可能解释了这种明显的矛盾。因此，金可以在“靶组织”中抑制类风湿性炎症，而在外周血中几乎没有抑制作用，在那里，由于活动性疾病导致的抑制性影响的消除可能被视为淋巴细胞反应性的净改善。
