Kjellman N I
Acta Paediatr Scand. 1977 Jul;66(4):465-71. doi: 10.1111/j.1651-2227.1977.tb07928.x.
The incidence of atopic disease and its relation to the family history was studied by questionnaire in 1325 children, 7 years of age. A higher incidence of bronchial asthma (2.7%) was found than in a previous Swedish study. The total incidence of atopic disease in the children was 15.1% with a higher level when there was a double parental history of such disease (42.6%) as compared with a single such history (19.8%). When both parents had an identical type of atopic disease, i.e. respiratory or skin, the incidence of atopic disease was higher (72.2%) than when non-identical types occurred in the parents (20.8%). The findings support theories of a polygenic transmission of atopic disease as well as a genetic influence on symptom specificity in such disease and may be of value in genetic counselling.
通过问卷调查研究了1325名7岁儿童的特应性疾病发病率及其与家族史的关系。发现支气管哮喘的发病率（2.7%）高于瑞典此前的一项研究。这些儿童特应性疾病的总发病率为15.1%，当父母双方都有此类疾病家族史时（42.6%），发病率高于只有一方有家族史的情况（19.8%）。当父母双方患有相同类型的特应性疾病，即呼吸道或皮肤疾病时，特应性疾病的发病率更高（72.2%），高于父母患有不同类型特应性疾病时的发病率（20.8%）。这些发现支持了特应性疾病多基因传递的理论以及遗传因素对该疾病症状特异性的影响，可能对遗传咨询有一定价值。
