含N-甲基抗肿瘤药物的代谢研究：给小鼠施用14C标记的N-甲基药物、甲醛和甲酸后的14CO2呼气分析。 - Suppr

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Studies of the metabolism of N-methyl containing anti-tumour agents: 14CO2 breath analysis after administration of 14C-labelled N-methyl drugs, formaldehyde and formate in mice.

作者信息

Gescher A, Raymont C

出版信息

Biochem Pharmacol. 1981 Jun 1;30(11):1245-52. doi: 10.1016/0006-2952(81)90305-1.

DOI:10.1016/0006-2952(81)90305-1

PMID:6791650

Abstract

摘要

相似文献

Studies of the metabolism of N-methyl containing anti-tumour agents: 14CO2 breath analysis after administration of 14C-labelled N-methyl drugs, formaldehyde and formate in mice.含N-甲基抗肿瘤药物的代谢研究：给小鼠施用14C标记的N-甲基药物、甲醛和甲酸后的14CO2呼气分析。

Biochem Pharmacol. 1981 Jun 1;30(11):1245-52. doi: 10.1016/0006-2952(81)90305-1.

Effect of ethanol and metabolic substrates on the oxidation of aminopyrine, formaldehyde and formate by isolated hepatocytes.乙醇和代谢底物对分离的肝细胞氧化氨基比林、甲醛和甲酸的影响。

J Pharmacol Exp Ther. 1983 Dec;227(3):687-93.

Reduction of hepatic tetrahydrofolate and inhibition of exhalation of 14CO2 formed from [dimethylamino-14C]aminopyrine in nitrous oxide-treated rats.一氧化二氮处理的大鼠肝脏中四氢叶酸的减少以及由[二甲基氨基-¹⁴C]氨基比林形成的¹⁴CO₂呼出的抑制。

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Effect of glutathione depletion on aminopyrine and formaldehyde metabolism.谷胱甘肽耗竭对氨基比林和甲醛代谢的影响。

Biochem Pharmacol. 1988 Apr 15;37(8):1581-9. doi: 10.1016/0006-2952(88)90021-4.

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Pharmacokinetic and deuterium isotope effect studies on the metabolism of formaldehyde and formate to carbon dioxide in rats in vivo.

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The effect of glutathione depletion on 14CO2 evolution from [14C]methyl-labeled aminopyrine in intact rats.

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Studies on lung tumours. III. Oxidative metabolism of dimethylnitrosamine by rodent and human lung tissue.肺部肿瘤研究。III. 啮齿动物和人类肺组织对二甲基亚硝胺的氧化代谢

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Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism.

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Output of 14CO2 in breath after oral administration of (14C-methyl) aminopyrine in hepatitis, cirrhosis and hepatic bilharziasis: its relationship to aminopyrine pharmacokinetics.

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引用本文的文献

N-methylformamide: antitumour activity and metabolism in mice.N-甲基甲酰胺：小鼠体内的抗肿瘤活性及代谢

Br J Cancer. 1982 Jun;45(6):843-50. doi: 10.1038/bjc.1982.136.

A kinetic evaluation of 14CO2 in expired air after 14C-methacetin administration in rats, used for the in vivo study of the metabolism of drugs.在大鼠体内给予14C-甲醋卡因后，对呼出气体中14CO2进行动力学评估，用于药物代谢的体内研究。

Eur J Drug Metab Pharmacokinet. 1984 Apr-Jun;9(2):161-8. doi: 10.1007/BF03189620.

The antipyrine breath test in the rat: a pharmacokinetic model.

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):207-14. doi: 10.1007/BF03189941.

A qualitative study on vanadate effects in the tetrahydrofolate-dependent formate transfer in vitro and in vivo in mice.一项关于钒酸盐对小鼠体内外四氢叶酸依赖性甲酸转移作用影响的定性研究。

Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):111-6. doi: 10.1007/BF00177760.

The 14CO2 breath test: facilities and limitations of a rapid and noninvasive method for in vivo evaluation of modified hepatic cytochrome P-450--a critique.

Arch Toxicol. 1987;60(1-3):81-5. doi: 10.1007/BF00296953.

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