Angehrn P
Eur J Clin Microbiol. 1983 Oct;2(5):489-95. doi: 10.1007/BF02013914.
The antibacterial interaction between ceftriaxone and the aminoglycosides tobramycin, gentamicin and amikacin against pseudomonas aeruginosa was investigated in vitro and in experimental systemic infections of the mouse. In vitro synergy was observed in 70% of the strains with tobramycin, 67.5% with gentamicin, and 77.5% with amikacin. Synergistic bactericidal activity was demonstrated with all three aminoglycosides in combination with ceftriaxone. In line with these in vitro results, synergism against most isolates also occurred in mice. In leukopenic mice, the addition of ceftriaxone resulted in a more than 2.5-fold reduction of the aminoglycoside dose necessary for antiinfective protection, although ceftriaxone alone was only marginally active against the pathogen used in immunocompromised animals.
研究了头孢曲松与氨基糖苷类药物妥布霉素、庆大霉素和阿米卡星对铜绿假单胞菌的体外抗菌相互作用以及在小鼠实验性全身感染中的作用。在体外，70%的菌株与妥布霉素呈现协同作用，67.5%的菌株与庆大霉素呈现协同作用，77.5%的菌株与阿米卡星呈现协同作用。所有三种氨基糖苷类药物与头孢曲松联合使用均表现出协同杀菌活性。与这些体外结果一致，在小鼠中对大多数分离株也出现了协同作用。在白细胞减少的小鼠中，添加头孢曲松可使抗感染保护所需的氨基糖苷类药物剂量减少超过2.5倍，尽管头孢曲松单独使用时对免疫受损动物所使用的病原体仅有微弱活性。
