沙特阿拉伯利雅得产青霉素酶的淋病奈瑟菌
Penicillinase-producing Neisseria gonorrhoeae in Riyadh, Saudi Arabia.
作者信息
Chowdhury M N, Pareek S S, Mahgoub E S
出版信息
Br J Vener Dis. 1981 Aug;57(4):256-8. doi: 10.1136/sti.57.4.256.
Abstract
Of 83 strains of Neisseria gonorrhoeae isolated in Riyadh, Saudi Arabia, between April 1979 and August 1980, 10 produced beta-lactamase and had minimum inhibitory concentrations (MICs) of penicillin between 1 and greater than or equal to 4 micrograms/ml. Of the 73 (88%) non-penicillinase-producing strains, 55% had diminished sensitivity to penicillin (MIC = 0.06 micrograms/ml) and 11 (15%) were highly resistant (MICs ranging from 0.5-2 micrograms/ml). This high incidence of resistance may be due to widespread abuse of antibiotics; it also confirms that two mechanisms of resistance to penicillin exist in this species.
摘要
1979年4月至1980年8月间，在沙特阿拉伯利雅得分离出的83株淋病奈瑟菌中，10株产生β-内酰胺酶，青霉素最低抑菌浓度（MIC）在1至大于或等于4微克/毫升之间。在73株（88%）不产生青霉素酶的菌株中，55%对青霉素敏感性降低（MIC = 0.06微克/毫升），11株（15%）高度耐药（MIC范围为0.5 - 2微克/毫升）。这种高耐药发生率可能是由于抗生素的广泛滥用；这也证实了该菌种存在两种对青霉素的耐药机制。
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