Eckardt J J, Ivins J C, Perry H O, Unni K K
Cancer. 1981 Sep 1;48(5):1256-61. doi: 10.1002/1097-0142(19810901)48:5<1256::aid-cncr2820480534>3.0.co;2-4.
A patient with dermatomyositis developed malignant transformation of the benign interfascial heterotopic bone. This patient had classic childhood dermatomyositis at the age of 3 years, and the disease was arrested after a one-year course of corticosteroid therapy. Extensive subcutaneous calcinosis cutis and deep interfascial calcinosis were the residua of the disease. Twenty-eight years later, the patient developed a high-grade osteosarcoma within the benign intermuscular heterotopic calcification and ossification that had been previously documented at the age of 8 years by a roentgenogram and at the age of 16 years by biopsy. This case represents the first report of the association of osteosarcoma and dermatomyositis, and possibly the first well-documented case of malignant transformation of benign heterotopic bone.
一名皮肌炎患者发生了良性筋膜间异位骨的恶性转化。该患者3岁时患典型的儿童皮肌炎，经一年的皮质类固醇治疗后病情得到控制。广泛的皮下皮肤钙化和深部筋膜钙化是该疾病的残留表现。28年后，患者在良性肌间异位钙化和骨化部位发生了高级别骨肉瘤，该部位曾在8岁时经X线检查记录，并在16岁时经活检证实。本病例代表了骨肉瘤与皮肌炎关联的首例报告，也可能是良性异位骨恶性转化的首例有充分记录的病例。
