Setoguti T, Inoue Y, Kato K
Cell Tissue Res. 1981;219(3):457-67. doi: 10.1007/BF00209986.
In the rat parathyroid, the mean number of storage granules (NSG) per chief cell has been electron-microscopically studied and correlated with the mean serum calcium level (SCL). In animals given 4% CaCl2 plus vitamin D2 for 3 days. SCL is significantly elevated and NSG is increased. When these animals are injected with 2% EDTA, SCl is lowered to 8 mg/dl, but NSG is not affected; in those injected with 4% EDTA, however, SCL declines to a minimum (5.8 mg/dl) after 30 min, and NSG is also decreased. Control SCL are 8.9 mg/dl. These results indicate that storage granules may not be released until SCL is depressed to a certain level. In rats 3 weeks after castration, the chief cells show hyperplastic changes and SCl is at a low concentration (8.0 mg/dl). NSG, however, remains almost within control limits. Castrated animals injected with 4% EDTA show a hypocalcemia and a decrease in NSG, but NSG gradually recovers over a period of 6 h. These data suggest that storage granules can be produced even under lower calcium concentrations. It is concluded that storage granules may be constantly produced and stored, and are released only as an emergency supply of hormone.
在大鼠甲状旁腺中，已通过电子显微镜研究了每个主细胞中储存颗粒的平均数量（NSG），并将其与平均血清钙水平（SCL）相关联。给动物注射4%氯化钙加维生素D2 3天。SCL显著升高，NSG增加。当给这些动物注射2%乙二胺四乙酸（EDTA）时，SCL降至8mg/dl，但NSG不受影响；然而，在注射4%EDTA的动物中，30分钟后SCL降至最低（5.8mg/dl），NSG也减少。对照SCL为8.9mg/dl。这些结果表明，储存颗粒可能直到SCL降至一定水平才会释放。在阉割后3周的大鼠中，主细胞显示增生性变化，SCL处于低浓度（8.0mg/dl）。然而，NSG几乎保持在对照范围内。给阉割动物注射4%EDTA会出现低钙血症和NSG减少，但NSG在6小时内逐渐恢复。这些数据表明，即使在较低的钙浓度下也能产生储存颗粒。结论是，储存颗粒可能不断产生和储存，并且仅作为激素的应急供应而释放。
