Mohn G, Philipp E M
Lab Anim. 1981 Apr;15(2):89-95. doi: 10.1258/002367781780958982.
Mice given food containing fenbendazole to prevent a reinfection with Syphacia muris were treated with inducers of the hepatic microsomal monooxygenase system. Specific induction values and factors were the same as found previously in similar mice infected with Syphacia muris. There was a decrease in the total hepatic monooxygenase system by 20-40%, associated with a similar decrease in the total microsomal protein. As this was found in both experimental and control mice, the induction factors of the total values remained also unaltered. Thus infection by Syphacia muris not only retarded the growth of young mice but also accelerated the development of their hepatic monooxygenase system.
给小鼠喂食含芬苯达唑的食物以预防鼠管状线虫再次感染，并对其进行肝微粒体单加氧酶系统诱导剂处理。特异性诱导值和诱导因子与先前在感染鼠管状线虫的类似小鼠中发现的相同。肝单加氧酶系统总量下降了20%-40%，同时微粒体蛋白总量也有类似程度的下降。由于在实验小鼠和对照小鼠中均发现了这种情况，所以总量的诱导因子也保持不变。因此，鼠管状线虫感染不仅会阻碍幼鼠生长，还会加速其肝单加氧酶系统的发育。
