Mullin T J, Kirkpatrick J R
Surgery. 1981 Oct;90(4):610-5.
Thirty-nine patients, 25 of whom were suffering from trauma, sepsis, or malignant disease, were studied prospectively to determine the immunologic value of improved protein-calorie balance in this setting. All were suffering from varying degrees of malnutrition, and 72% (P less than 0.05) of the patients with anergy-inducing disease processes were anergic at the time of evaluation. In the presence of disease-induced anergy, skin test reactivity was not helpful in measuring the therapeutic response to nutritional support; among severely wasted patients, significant elevations in absolute lymphocyte count and serum albumin suggest that these are useful parameters when following the severely wasted patient who has concomitant trauma, sepsis, or malignant disease.
对39例患者进行了前瞻性研究，其中25例患有创伤、脓毒症或恶性疾病，以确定在这种情况下改善蛋白质-热量平衡的免疫学价值。所有患者均存在不同程度的营养不良，在评估时，患有诱导无反应性疾病过程的患者中有72%（P<0.05）表现为无反应性。在疾病诱导的无反应性存在的情况下，皮肤试验反应性无助于衡量对营养支持的治疗反应；在严重消瘦的患者中，绝对淋巴细胞计数和血清白蛋白的显著升高表明，对于伴有创伤、脓毒症或恶性疾病的严重消瘦患者，这些是有用的参数。
