Feichtinger W, Kemeter P, Salzer H, Friedrich F
Wien Klin Wochenschr. 1981 Mar 20;93(6):186-93.
77 amenorrhoeic women were classified as responding positively or negatively to clomiphene. The results of iterative LRH tests and studying feed-back reactions to steroid administration showed that the two collectives strictly correspond to groups I and II of the WHO classification of amenorrhoea. The LH response to the LRH test was significantly higher in group II than in group I, while there was no difference between the two groups in the FSH response. Oestradiol 17 beta was significantly higher in group II than in group I, but both groups showed a significant increase in E2 three hours after the LRH test. The possible mechanisms of LH production and pool formation, as well as FSH regulatory factors are discussed. This paper demonstrates that clomiphene appears to be ideally suited as a test substance for the classification of amenorrhoea according to its degree of severity.
77名闭经女性被分类为对克罗米芬反应阳性或阴性。反复进行促黄体生成素释放激素（LRH）试验的结果以及对甾体激素给药的反馈反应研究表明，这两组与世界卫生组织闭经分类中的I组和II组严格对应。II组对LRH试验的促黄体生成素（LH）反应显著高于I组，而两组之间促卵泡生成素（FSH）反应无差异。II组的17β-雌二醇显著高于I组，但两组在LRH试验后3小时雌二醇（E2）均显著升高。讨论了LH产生和储备形成的可能机制以及FSH调节因子。本文表明，克罗米芬似乎非常适合作为根据闭经严重程度进行分类的测试物质。
