Oda T
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jun;34(6):751-60.
Diagnostic evaluation of progesterone (P) challenge test (menstrual response and serum LH changes after P administration) was studied in 223 patients with secondary amenorrhea. Based on the serum FSH an prolactin (PRL) values amenorrheic patients were divided into three major groups; low or normal levels of FSH and PRL (Group I), high levels of PRL (Group II), high levels of FSH (Group III). Serum estradiol levels in patients with normal menstrual response to P were significantly higher than those with absent or scanty bleeding following P. Although the Group III patients with absent or scanty bleeding (Group IIIb) represented patients with ovarian failure, those with normal menstrual response to P (Group IIIa) clinically appeared to have high developed ovarian follicles. Based on the LH responses after P administration the Group I patients were further subdivided into two groups, one with LH increase following P (Group Ia) and the second with no LH increase (Group Ib). In Group Ia 92 percent ovulated with clomiphene but all in Group Ib failed to ovulate. Therefore the LH changes after P administration gave good prediction of ovulatory as well as anovulatory responses to clomiphene.
对223例继发性闭经患者进行了孕酮（P）激发试验（P给药后的月经反应和血清促黄体生成素（LH）变化）的诊断评估。根据血清促卵泡生成素（FSH）和催乳素（PRL）值，闭经患者被分为三大组：FSH和PRL水平低或正常（第一组）、PRL水平高（第二组）、FSH水平高（第三组）。对P有正常月经反应的患者血清雌二醇水平显著高于P给药后无出血或出血少的患者。虽然第三组中无出血或出血少的患者（第三组b）代表卵巢功能衰竭患者，但对P有正常月经反应的患者（第三组a）临床上似乎有发育良好的卵巢卵泡。根据P给药后的LH反应，第一组患者进一步分为两组，一组P给药后LH升高（第一组a），另一组LH无升高（第一组b）。在第一组a中，92%的患者使用克罗米芬后排卵，但第一组b中的所有患者均未排卵。因此，P给药后的LH变化对克罗米芬的排卵和无排卵反应有很好的预测作用。
