Williams M H
Ann Intern Med. 1981 Oct;95(4):464-7. doi: 10.7326/0003-4819-95-4-464.
Experience with beclomethasone dipropionate during the past 5 years has confirmed and extended the original observation that it is an effective, topically active corticosteroid of great value in treating asthma. Most steroid-dependent asthmatic patients can be successfully controlled with the drug, at least most of the time, and the therapeutic effect is dose dependent. Although high doses may be associated with some adrenal suppression such doses do not cause systemic symptoms, and side effects are of little consequence. It is important that patients treated with steroid aerosols continue to receive other effective therapeutic agents, notably adrenergic drugs, particularly by aerosol, and theophylline compounds; that they learn how to inhale the aerosol properly; and, most important, that they promptly start taking oral steroids when they experience an exacerbation of asthma.
过去5年使用二丙酸倍氯米松的经验证实并拓展了最初的观察结果,即它是一种有效的、局部活性的皮质类固醇,在治疗哮喘方面具有重要价值。大多数依赖类固醇的哮喘患者至少在大多数时候可以通过该药成功控制病情,且治疗效果呈剂量依赖性。尽管高剂量可能会导致一些肾上腺抑制,但此类剂量不会引起全身症状,副作用也微不足道。使用类固醇气雾剂治疗的患者继续接受其他有效治疗药物非常重要,尤其是肾上腺素能药物,特别是气雾剂形式的,以及茶碱类化合物;他们要学会正确吸入气雾剂;最重要的是,当哮喘发作时,他们要立即开始口服类固醇药物。