Douglas J G, Munro J F, Kitchin A H, Muir A L, Proudfoot A T
Br Med J (Clin Res Ed). 1981 Oct 3;283(6296):881-3. doi: 10.1136/bmj.283.6296.881.
Pulmonary hypertension developed in two women who had been taking fenfluramine for over eight months for weight reduction. On withdrawing the drug symptoms and electrocardiographic evidence of pulmonary hypertension disappeared in both cases. In one patient, however, the evidence recurred after rechallenge with fenfluramine.These findings are strong evidence that fenfluramine may cause pulmonary hypertension. Hence any patient taking the drug should report immediately any deterioration in exercise tolerance.
两名女性因减肥服用芬氟拉明超过八个月后出现了肺动脉高压。停用该药物后，两名患者的肺动脉高压症状及心电图证据均消失。然而，其中一名患者在再次服用芬氟拉明后，症状再次出现。这些发现有力地证明了芬氟拉明可能会导致肺动脉高压。因此，任何服用该药物的患者若运动耐量出现任何恶化都应立即报告。
