Taylor K G, Wright A D, Carter T J, Valente A J, Betts S A, Matthews K A
Diabetologia. 1981 May;20(5):535-9. doi: 10.1007/BF00252761.
High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1 (HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hyper-triglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL-cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p Less Than 0.005). Decreased HDL-cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.
与按性别、年龄、肥胖、饮酒和吸烟情况匹配的对照人群相比，非胰岛素依赖型糖尿病患者在诊断时高密度脂蛋白（HDL）胆固醇水平降低。血清HDL胆固醇浓度与糖化血红蛋白A1（HbA1）百分比之间无关联。在整个血清甘油三酯水平范围内，糖尿病患者的血清HDL胆固醇水平较低，尤其是高甘油三酯血症糖尿病患者。血清甘油三酯水平正常的糖尿病患者血清载脂蛋白A-I水平未降低，因此糖尿病患者HDL胆固醇与载脂蛋白A-I的比值显著降低（p＜0.005）。非胰岛素依赖型糖尿病患者HDL胆固醇水平降低可能与动脉粥样硬化的后续发展有关。
