钙调节小鼠红白血病细胞向终末红细胞分化的进程。
Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation.
作者信息
Bridges K, Levenson R, Housman D, Cantley L
出版信息
J Cell Biol. 1981 Aug;90(2):542-4. doi: 10.1083/jcb.90.2.542.
Abstract
An alteration in the rate of calcium transport appears to be the rate-limiting event for the commitment of murine erythroleukemia (MEL) cells to initiate a program of terminal erythroid differentiation. The dimethyl sulfoxide (DMSO)-induced commitment of MEL cells to erythroid differentiation can be inhibited by treatment of cells with the calcium-chelating agent EGTA. Upon removal of EGTA, cells initiate commitment without the 12-h lag normally observed after treatment with DMSO alone. Treatment of cells with DMSO in the presence of calcium ionophore A23187 causes cells to initiate commitment from time zero with no lag. These results suggest that the lag is the time required for DMSO to alter the calcium transport properties of the cell.
摘要
钙转运速率的改变似乎是小鼠红白血病（MEL）细胞启动终末红细胞分化程序的限速事件。用钙螯合剂乙二醇双四乙酸（EGTA）处理细胞可抑制二甲基亚砜（DMSO）诱导的MEL细胞向红细胞分化。去除EGTA后，细胞可启动分化，且没有单独用DMSO处理后通常观察到的12小时延迟。在钙离子载体A23187存在的情况下用DMSO处理细胞，可使细胞从零时开始启动分化，没有延迟。这些结果表明，延迟是DMSO改变细胞钙转运特性所需的时间。
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本文引用的文献
1
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Nature. 1980 Oct 9;287(5782):558-60. doi: 10.1038/287558a0.
2
Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.氨氯吡咪抑制小鼠红白血病细胞分化：分化起始需要钙离子的证据。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5948-52. doi: 10.1073/pnas.77.10.5948.
3
Effect of calcium on differentiation of Friend leukemia cells.钙对弗瑞德白血病细胞分化的影响。
Dev Biol. 1980 Sep;79(1):243-6. doi: 10.1016/0012-1606(80)90088-3.
4
Calcium regulation of growth and differentiation of mouse epidermal cells in culture.培养的小鼠表皮细胞生长和分化的钙调节
Cell. 1980 Jan;19(1):245-54. doi: 10.1016/0092-8674(80)90406-7.
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6
Commitment to erythroid differentiation by friend erythroleukemia cells: a stochastic analysis.Friend红白血病细胞向红系分化的趋向性：一项随机分析。
Cell. 1976 Oct;9(2):221-9. doi: 10.1016/0092-8674(76)90113-6.
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Induction of erythroid differentiation in vitro by purines and purine analogues.嘌呤及嘌呤类似物在体外诱导红细胞分化
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