Busachi C A, Realdi G, Alberti A, Badiali-De Giorgi L, Tremolada F
J Med Virol. 1981;7(3):205-12. doi: 10.1002/jmv.1890070304.
Electron microscopy examination of liver biopsies from 8 patients with chronic non-A, non-B hepatitis revealed ultrastructural changes similar to those previously described in chimpanzees with experimentally induced acute non-A, non-B hepatitis. These changes consisted of intranuclear clusters of electron-dense, 15-27-nm particles that were detected in five out of the eight patients and of circular cytoplasmic structures that were present in seven cases. Other cytoplasmic abnormalities found in our patients related to the presence of curved membranes apparently developing from apposition of two cisternae of endoplasmic reticulum. In contrast with what has been reported in infected chimpanzees, the nuclear and cytoplasmic changes were not mutually exclusive in our patients, but coexisted in four of them.
对8例慢性非甲非乙型肝炎患者的肝活检组织进行电子显微镜检查，结果显示其超微结构变化与先前在实验性诱发急性非甲非乙型肝炎的黑猩猩中所描述的变化相似。这些变化包括在8例患者中的5例中检测到的核内电子致密的15 - 27纳米颗粒簇，以及7例中存在的圆形细胞质结构。在我们的患者中发现的其他细胞质异常与明显由内质网的两个池并列形成的弯曲膜的存在有关。与感染黑猩猩的报道不同，在我们的患者中，核变化和细胞质变化并非相互排斥，而是在其中4例中共存。
