Anderson M, Murray-Lyon I M, Coleman J C, McCaul T F, Bird R G, Tovey G, Zuckerman A J
J Med Virol. 1982;9(3):217-29. doi: 10.1002/jmv.1890090309.
Ultrastructural changes in a liver biopsy obtained for diagnostic purposes from a patient with suspected non-A, non-B hepatitis were consistent with hepatitis and included dilatation and disaggregation of the endoplasmic reticulum, hepatocyte disarray, and variations in mitochondrial size. In addition, some foci of hepatocytes showed atypical cytoplasmic changes including intranuclear cytoplasmic pseudo-inclusions, consisting basically of invaginations of the cytoplasmic mass into the nucleus, glycogen deposits in the same nuclei, and frequently accumulations of fat droplets. The mitochondria were generally pleomorphic, and occasionally the mitochondrial cristae were arranged longitudinally. Dilatation, hypertrophy, and distortion of the Golgi complexes were found in affected hepatocytes. Similar ultrastructural changes have previously been reported in human hepatocellular carcinoma as well as in carcinomas of other tissues.
从一名疑似非甲非乙型肝炎患者身上获取的用于诊断目的的肝脏活检组织的超微结构变化与肝炎相符，包括内质网扩张和分散、肝细胞排列紊乱以及线粒体大小变化。此外，一些肝细胞灶显示出非典型的细胞质变化，包括核内细胞质假包涵体，其基本由细胞质团块向细胞核内凹陷、同一细胞核内的糖原沉积以及脂肪滴频繁积聚组成。线粒体通常形态多样，偶尔线粒体嵴呈纵向排列。在受影响的肝细胞中发现了高尔基体的扩张、肥大和变形。此前在人类肝细胞癌以及其他组织的癌中也报道过类似的超微结构变化。
