Wägar G, Tolonen M, Stenman U H, Helpiö E
J Toxicol Environ Health. 1981 Mar-Apr;7(3-4):363-71. doi: 10.1080/15287398109529987.
The effect of long-term occupational exposure to CS2 on various endocrinologic parameters was studied in 15 exposed men and 16 age-matched controls. Duration of exposure varied between 10 and 36 yr. The CS2 concentrations in the viscose rayon plant have been below the Finnish threshold limit value of 30 mg/m3 (10 ppm) under normal operating conditions for the past 10 yr. Before this the exposure was considerably greater. Of the various endocrinologic parameters, serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) were significantly increased in the exposed group, seven workers having values above the reference limit. This was taken as a sign of primary gonadal insufficiency, which was considered only latent as serum testosterone values were unaffected. No changes were seen in serum prolactin values before or after stimulation with thyrotropin releasing hormone (TRH). No disturbance was seen in thyroid function as evaluated by serum thyroxine (T4), free thyroxine index (FT1), triiodothyronine (T3), and the thyrotropin response to TRH. Serum cortisol was also unchanged. These results may reflect high exposure during past decades rather than exposure to the present low CS2 concentrations.
对15名接触二硫化碳的男性和16名年龄匹配的对照者进行了长期职业接触二硫化碳对各种内分泌参数影响的研究。接触时长在10至36年之间。在过去10年的正常运行条件下，粘胶纤维厂的二硫化碳浓度一直低于芬兰30毫克/立方米（10 ppm）的阈限值。在此之前，接触程度要高得多。在各种内分泌参数中，接触组的血清促卵泡激素（FSH）和促黄体生成素（LH）显著升高，7名工人的值高于参考限值。这被视为原发性性腺功能不全的迹象，由于血清睾酮值未受影响，所以认为只是潜在的。用促甲状腺激素释放激素（TRH）刺激前后，血清催乳素值均未见变化。通过血清甲状腺素（T4）、游离甲状腺素指数（FT1）、三碘甲状腺原氨酸（T3）以及TRH刺激后的促甲状腺激素反应评估，甲状腺功能未见紊乱。血清皮质醇也未改变。这些结果可能反映的是过去几十年的高接触情况，而非目前低二硫化碳浓度的接触情况。
