Paladini G, Sala P G
Acta Haematol. 1981;66(1):31-4. doi: 10.1159/000207088.
In 12 myeloma patients responding to chemotherapy (7 IgG and 5 IgA), we studied the effect on the anion gap of a 50% reduction in the serum paraprotein concentration. In contrast to the pretreatment anion gap which was decreased in IgG myeloma and increased in IgA myeloma, the value calculated when the paraprotein spike was halved showed a tendency towards normalization in the former type of myeloma, whereas it appeared as quite normalized in the latter. Our results lend further support to the conceptions that IgG and IgA paraproteins behave in the serum as cations and anions, respectively, and that serial determinations of the anion gap may be of value for monitoring the response to treatment in patients with multiple myeloma.
在12例对化疗有反应的骨髓瘤患者（7例IgG型和5例IgA型）中，我们研究了血清副蛋白浓度降低50%对阴离子间隙的影响。与预处理时IgG型骨髓瘤患者阴离子间隙降低、IgA型骨髓瘤患者阴离子间隙升高不同，当副蛋白峰减半时计算得出的值显示，前一种类型的骨髓瘤有趋于正常化的趋势，而后一种类型则似乎已完全正常化。我们的结果进一步支持了以下观点：IgG和IgA副蛋白在血清中分别表现为阳离子和阴离子，并且连续测定阴离子间隙可能对监测多发性骨髓瘤患者的治疗反应有价值。
